Questions to Ask About Cord Blood Banking - Baby Chick
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Questions to Ask About Cord Blood Banking

Here are the important things to ask about cord blood banking.

Sponsored by: The image shows the Americord logo. It features a colorful circular design with the brand name
Published January 24, 2017

by Nina Spears

The Baby Chick®: Pregnancy, Birth & Postpartum Expert

You’ve probably heard of cord blood banking. More parents are taking advantage of this service as it becomes increasingly popular. You might also consider banking your baby’s cord blood, but you probably have many questions. I get it. Cord blood banking is a bit of an obscure business, and I had a lot of questions myself. It is important to ask the right questions when talking to different banks. You want to choose the right cord blood bank for you and your family.

Questions to Ask When Considering Cord Blood Banking

Here are all the critical questions you will want to ask before signing on the dotted line.

Product Quality

There are a few questions that you will want to ask to ensure you are getting a quality product for your time and money:

1. What volume do you recommend collecting, and what happens if I fail to collect the minimum?

2. How many stem cells can I expect to store?

3. How do you freeze the cord blood?

Find out how they ensure they store and monitor your cord blood safely. What freezers do they use? Do they freeze the cord blood in a separate freezer or mix it with other types of samples? Do they use liquid nitrogen or vapor nitrogen?

4. Do you store cord blood in a single unit or in compartments?

For transplants, it is irrelevant because you want as many cells as possible, so they will use the entire unit of cord blood. However, if scientific research advances and treatments and therapies are developed where you only need a small number of cells, then storing the cord blood in compartments could be advantageous because it will allow usage of the cord blood one portion at a time.

5. What processing technique do you use?

Cord blood banking companies use various processing methods to ensure the highest probability of success. Ask what type of processing the bank uses and why they believe it to be superior.

6. What types of tests do you run on maternal blood?

You will want to know if any of these tests can justify rejecting the samples.

7. Do you test the stem cells for viability before storing them? For example, testing for infectious diseases?

What happens if your child’s cord blood tests positive for one of these diseases?

8. Can your bank change storage facilities?

Find out if the bank reserves the right to change storage facilities. And if they do, what type of quality guarantee do you have regarding the new facility? How can they assure you they will safely transport cord blood from one facility to another?

9. Does your cord blood bank have clinical experience?

Ask the banks you’re considering how much of their customers’ cord blood has been used for transplants and other therapies. Experience releasing cord blood for transplants and participating in experimental therapies indicates the company is successful with clinical applications of cord blood. It confirms that they are storing the blood carefully enough for the stem cells to be viable when they remove it from the freezer.

Be wary of a bank with many cord blood units in storage but never use a unit for a transplant. It could mean that doctors have rejected their cord blood — a warning that the bank’s procedures may not be careful or thorough enough. If the bank is new, you can’t expect it to have years of clinical experience. But it’s reassuring if the people operating the company have a proven track record.

10. What are your facility’s credentials? Does your bank meet federal, state, and accreditation requirements?

The cord blood bank you use must have accreditation by the Association for the Advancement of Blood & Biotherapies (AABB) to procure, process, and store umbilical cord blood stem cells for transplantation. The AABB is the only accreditation that ensures high standards regarding the quality of the processing and storage of your baby’s cord blood.
Some banks are fee-paying members of the AABB, but that’s not the same as being fully accredited. For accreditation, the cord blood banking company must have its laboratory and administrative procedures reviewed, inspected, and validated regularly, and its procedures must comply with AABB guidelines for cord blood processing.

The FDA should also approve the cord blood bank’s methods and protocols, and the bank should be able to show all necessary state registrations and licenses.

11. Is the company committed to research for future applications of cord blood?

Look for a company that actively participates and invests in researching and developing cord blood stem cell therapies. If a cord blood company is committed to research, it’s a good indication it is also committed to the future, which means they are more likely to have financial stability.

Product Safety

Ensuring the safety of both you and your cord blood or tissue is essential.

1. How does your company collect and store my child’s cord blood?

Look for a company that uses the gravity bag collection method (vs. the syringe method). The gravity bag is the collection method preferred by doctors and is designed to collect the greatest volume of cord blood. It’s the industry standard method used by most blood banks and is similar to the American Red Cross and the National Institutes of Health methods. In addition, the closed tube/bag system eliminates exposure to airborne bacteria and greatly reduces the likelihood of contamination during collection.

2. Where do you store the cord blood?

Find out exactly where the laboratory is and ensure it is within a safe distance from the delivery location to ensure a high probability of successful transportation. You’ll also want to be sure that your cord blood bank has state-of-the-art facilities and provides maximum security and protection.

3. How do you deliver the umbilical cord collection kit to the facility, and where do you process it?

Ideally, you can have the collection kit delivered by personal courier or overnight FedEx for greater distances. Cord blood and cord tissue should always be kept at room temperature.

4. Does your cord blood bank provide shipping with thermal integrity?

Shipping the cord blood to the laboratory is the crucial first step in safeguarding your baby’s stem cells. There are two ways banks can protect the cord blood in transit. One approach commonly used for donated cord blood is to ship it in a heavily insulated box. These containers have so much thermal protection that cord blood can be sent via FedEx. Priority shipping services like FedEx guarantee arrival time but do not guarantee temperature conditions during transit.

The second approach, used by many family cord blood banks, is shipping in smaller boxes with less thermal protection that are carried by medical couriers. These couriers guarantee that boxes are kept in a passenger compartment where the temperature is in a safe range.

5. Does the FDA approve your collection kit for C-sections (sterilized both inside and outside)?

Be sure the company you are looking at provides a sterile collection protocol to allow for collections to be performed during C-sections and emergency births.

6. Does the bank process cord blood within 48 hours?

Quick and proper transportation of the cord blood is crucial. Agencies that oversee cord blood transplants have set a limit of 48 hours on the time between birth and processing the cord blood for cryogenic storage. So you’ll want to ensure your bank processes cord blood within 48 hours after the birth.

Customer Experience

1. How can I access my stem cells in the future?

Hopefully, you will never need to use your baby’s cord blood. However, should you need to use the stem cells from your stored cord blood, it is important that you feel confident in the process and system used by the cord blood bank to carry your stem cells to the correct location safely.

2. Will the laboratory notify me once it receives, processes, and tests the cord blood?

Find out if the laboratory will contact you or if you will be responsible for getting a hold of them. You will also want to know the final cell count.

Hidden Fees

Unfortunately, there can be hidden fees with some companies. Here are some questions to ask:

1. What is the total cost of cord blood banking, including storage and all fees?

Be sure to get a full breakdown of every cost, including long-term storage (for 20 years or more). Sometimes a low price is shown upfront, but then hidden fees continue to add up over time. Be sure to find out if there are programs, discounts, promotions, and payment plans to accommodate your specific needs.

2. Are there any non-refundable fees should I need to cancel for any reason?

3. Is the annual storage fee fixed, or might it increase later?

4. Does the lab HLA type the sample?

Before a transplant occurs, HLA typing is required to match the donor and patient. However, since HLA typing can cost several hundred dollars, there is no real reason to incur this cost until a transplant is needed. Find out if the bank insists on HLA typing the sample prior to the need for a transplant, and if so, what the fees are for this service.

5. Are there any additional processing fees upon withdrawal?


1. How long has your company been preserving cord blood?

2. Do you have customer reviews that you can share with me?

3. Is your bank financially stable and profitable?

Cord blood banking is a business, and businesses do go bankrupt. Fortunately, if a cord blood bank goes out of business, another company invariably takes over the frozen inventory. While it is reassuring that you’re unlikely to lose your child’s cord blood, it’s not desirable to have it moved from one lab to another. Or worse, to wonder whether it was maintained properly in the waning days of the failed company.

4. Do you have an insurance plan or partnerships with other companies to cover inventory in case of a natural disaster or business failure?

You should also find out if the company is a division of a larger corporation and whether there are academic affiliations, research collaborations, and equity partnerships with major biotechnology companies. This would prove the company is committed to researching and developing further applications for cord blood stem cell therapy and will most likely be around for the long run.

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Nina Spears The Baby Chick®: Pregnancy, Birth & Postpartum Expert
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Nina is The Baby Chick® & Editor-in-Chief of Baby Chick®. She received her baby planning certification in early 2011 and began attending births that same year. Since then, Nina has… Read more

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